Diagnosis Diagnosis and and management management of of

Diagnosis Diagnosis and and management management of of Hypertension Hypertension Dr. Kauser Usman (MD) Associate Professor Department of Medicine King George’s Medical University, Lucknow

Hypertension is defined as systolic blood pressure (SBP) of 140 mmHg or greater, diastolic blood pressure (DBP) of 90 mmHg or greater, or taking antihypertensive medication. VI JNC, 1997

Types of hypertension Essential hypertension – 95% – No underlying cause Secondary hypertension – Underlying cause

Causes of Secondary Hypertension Renal – Parenchymal – Vascular – Others Endocrine Miscellaneous Unknown

Classification

Blood Pressure Classification BP Classification Normal SBP mmHg 120 and DBP mmHg 80 Prehypertension 120–139 or 80–89 Stage 1 Hypertension 140–159 or 90–99 Stage 2 Hypertension 160 or 100

Incidence in India 25% of urban population and 10 % of rural population suffer from hypertension 70% of all hypertensive patients are stage I hypertension 12% of all hypertensive suffer from isolated systolic hypertension

Who are at risk ?

Hypertension: Predisposing factors Advancing Age Sex (men and postmenopausal women) Family history of cardiovascular disease Sedentary life style & psycho-social stress Smoking ,High cholesterol diet, Low fruit consumption Obesity & wt. gain Co-existing disorders such as diabetes, and hyperlipidaemia High intake of alcohol

Haemodynamic Pattern in Hypertension Young : BP CO X TPR Elderly : BP CO X TPR

Aetiology of Systemic Hypertension Secondary HTN (05%) A. Renal (80%) AGN CGN, CPN, Polycyst. K.D B. Endocrine Adrenal Primary aldosteronism Cushing’s syndrome Pheochromocytoma Acromegaly Exogenous hormone Hypothyroidism & Hyperparathyroidism Renal Artery stenosis Oral contraceptive Glucocorticoids Continue

Aetiology of Systemic Hypertension Others – Coarctation of the aorta – Pregnancy Induced HTN (Pre-eclampsia) – Sleep Apnea Syndrome.

Why to treat ?

Diseases Attributable to Hypertension Heart Left Ventricular Gangrene of the Failure Hypertrophy Myocardial Lower Extremities Infarction Coronary Heart Disease Aortic Aneurym HYPERTENSION Blindness Hypertensive encephalopathy Cerebral Chronic Stroke Preeclampsia/ Hemorrhage Kidney Eclampsia Failure Adapted from Dustan HP et al. Arch Intern Med. 1996; 156: 1926-1935

Target Organ Damage Heart Left ventricular hypertrophy Angina or myocardial infarction Heart failure Brain Stroke or transient ischemic attack Chronic kidney disease Peripheral arterial disease Retinopathy

CVD Risk The BP relationship to risk of CVD is continuous, consistent, and independent of other risk factors. Prehypertension signals the need for increased education to reduce BP in order to prevent hypertension.

Diagnosis

Clinical manifestations No specific complains or manifestations other than elevated systolic and/or diastolic BP (Silent Killer ) Morning occipital headache Dizziness Fatigue In severe hypertension, epistaxis or blurred vision

Self-Measurement of BP Provides information on: 1. Response to antihypertensive therapy 2. Improving adherence with therapy 3. Evaluating white-coat HTN Home measurement of 135/85 mmHg is generally considered to be hypertensive. Home measurement devices should be checked regularly.

Measuring Blood Pressure Patient seated quietly for at least 5minutes in a chair, with feet on the floor and arm supported at heart level An appropriate-sized cuff (cuff bladder encircling at least 80% of the arm) At least 2 measurements Continue

Measuring Blood Pressure Systolic Blood Pressure is the point at which the first of 2 or more sounds is heard Diastolic Blood Pressure is the point of disappearance of the sounds (Korotkoff 5th) Continue

Measuring Blood Pressure Ambulatory BP Monitoring - information about BP during daily activities and sleep. Correlates better than office measurements with target-organ injury. Continue

Laboratory Tests Routine Tests Electrocardiogram Urinalysis Blood glucose, Serum potassium, creatinine, or the corresponding estimated GFR, and calcium Lipid profile, after 9- to 12-hour fast, that includes high-density and low-density lipoprotein cholesterol, and triglycerides Optional tests Measurement of urinary albumin excretion or albumin/creatinine ratio More extensive testing for identifiable causes is not generally indicated unless BP control is not achieved

How to treat ?

Treatment Overview Goals of therapy Lifestyle modification Pharmacologic treatment Algorithm for treatment of hypertension Follow up and monitoring

Goals of Therapy Reduce Cardiac and renal morbidity and mortality. Treat to BP 140/90 mmHg or BP 130/80 mmHg in patients with diabetes or chronic kidney disease.

Non pharmacological Treatment of hypertension DASH diet Regular exercise Loose weight , if obese Reduce salt and high fat diets Avoid harmful habits ,smoking ,alcohal

Life style modifications Lose weight, if overweight Increase physical activity Reduce salt intake Stop smoking Limit intake of foods rich in fats and cholesterol increase consumption of fruits and vegetables Limit alcohol intake

Lifestyle Modification Modification Weight reduction Approximate SBP reduction (range) 5–20 mmHg / 10 kg weight loss Adopt DASH eating plan Dietary sodium reduction Physical activity 8–14 mmHg Moderation of alcohol consumption 2–4 mmHg 2–8 mmHg 4–9 mmHg

Antihypertensive Antihypertensive Drugs Drugs AT1 receptor ARB Continue .

Drug therapy for hypertension Class of drug Diuretics Example dose Initiating dose Usual maintenance Hydrochlorothiazide 12.5 mg o.d. 12.5-25 mg o.d. Atenolol 25-50 mg o.d. 50-100 mg o.d. Amlodipine 2.5-5 mg o.d. 5-10 mg o.d. -blockers prazosin 2.5 mg o.d ACE- inhibitors ramipril 1.25-5 mg o.d. 5-20 mg o.d. Angiotensin-II receptor blockers Losartan 25-50 mg o.d. 50-100 mg o.d. -blockers Calcium channel blockers 2.5-10mg o.d.

Diuretics Example: Hydrochlorothiazide Act by decreasing blood volume and cardiac output Decrease peripheral resistance during chronic therapy Drugs of choice in elderly hypertensives Side effects Hypokalaemia Hyponatraemia Hyperlipidaemia Hyperuricaemia (hence contraindicated in gout) Hyperglycaemia (hence not safe in diabetes) Not safe in renal and hepatic insufficiency

Beta blockers Example: Atenolol, Metoprolol, nebivolol, Block 1 receptors on the heart Block 2 receptors on kidney and inhibit release of renin Decrease rate and force of contraction and thus reduce cardiac output Drugs of choice in patients with co-existent coronary heart disease Side effects lethargy, impotency, bradycardia Not safe in patients with co-existing asthma and diabetes Have an adverse effect on the lipid profile

Calcium channel blockers Example: Amlodipine Block entry of calcium through calcium channels Cause vasodilation and reduce peripheral resistance Drugs of choice in elderly hypertensives and those with co-existing asthma Neutral effect on glucose and lipid levels Side effects Flushing, headache, Pedal edema

ACE inhibitors Example: Ramipril, Lisinopril, Enalapril Inhibit ACE and formation of angiotensin II and block its effects Drugs of choice in co-existent diabetes mellitus, Heart failure Side effectsdry cough, hypotension, angioedema

Angiotensin II receptor blockers Example: Losartan Block the angiotensin II receptor and inhibit effects of angiotensin II Drugs of choice in patients with coexisting diabetes mellitus Side effectssafer than ACEI, hypotension,

Alpha blockers Example: prazosin Block -1 receptors and cause vasodilation Reduce peripheral resistance and venous return Exert beneficial effects on lipids and insulin sensitivity Drugs of choice in patients with co-existing BPH Side effectsPostural hypotension,

Antihypertensive therapy: Side-effects and Contraindications Class of drugs Main side-effects Contraindications/ Special Precautions Diuretics Anuria (e.g. Hydrochlorothiazide) Electrolyte imbalance, Hypersensitivity, -blockers (e.g. Atenolol) Conduction Impotence, Bradycardia, Fatigue total and LDL cholesterol levels, HDL cholesterol levels, glucose levels, uric acid levels Bradycardia, disturbances, Diabetes, Asthma, Severe cardiac failure

Algorithm for Treatment of Hypertension Lifestyle Modifications Not at Goal Blood Pressure ( 140/90 mmHg) ( 130/80 mmHg for those with diabetes or chronic kidney disease) Initial Drug Choices Without Compelling Indications With Compelling Indications Stage 1 Hypertension Stage 2 Hypertension (SBP 140–159 or DBP 90–99 mmHg) Thiazide-type diuretics for most. May consider ACEI, ARB, BB, CCB, or combination. (SBP 160 or DBP 100 mmHg) 2-drug combination for most (usually thiazide-type diuretic and ACEI, or ARB, or BB, or CCB) Not at Goal Blood Pressure Optimize dosages or add additional drugs until goal blood pressure is achieved. Consider consultation with hypertension specialist. Drug(s) for the compelling indications Other antihypertensive drugs (diuretics, ACEI, ARB, BB, CCB) as needed.

Choice of Drug Condition Preferred drugs Asthma Calcium channel blockers Diabetes mellitus -blockers/ACE inhibitors/ Angiotensin-II receptor blockers -blockers High cholesterol levels Elderly patients (above 60 years) Calcium channel blockers/Diuretics BPH -blockers Other drugs that can be used -blockers/Angiotensin-II receptor blockers/Diuretics/ ACE-inhibitors Calcium channel blockers Drugs to be avoided -blockers ACE inhibitors/ A-II receptor blockers/ Calcium channel blockers -blockers/ACEinhibitors/Angiotensin-II receptor blockers/ - blockers -blockers/ ACE inhibitors/ Angiotensin-II receptor blockers/ Diuretics/ Calcium channel blockers -blockers/ Diuretics Diuretics/ -blockers

Antihypertensive therapy: Sideeffects and Contraindications (Contd.) Class of drug Main side-effects Contraindications/ Special Precautions Calcium channel blockers (e.g. Amlodipine, Diltiazem) Pedal edema, Headache Non-dihydropyridine CCBs (e.g diltiazem)– Hypersensitivity, Bradycardia, Conduction disturbances, CHF, LV dysfunction. -blockers (e.g. prazosin) Postural hypotension Hypersensitivity ACE-inhibitors (e.g. Lisinopril) Cough, Hypotension, Angioneurotic edema Hypersensitivity, Pregnancy, Bilateral renal artery stenosis Angiotensin-II receptor blockers (e.g. Losartan) Headache, Dizziness Hypersensitivity, Pregnancy, Bilateral renal artery stenosis

Condition Preferred Drugs Pregnancy Nifedipine, labetalol, hydralazine, beta-blockers, methyldopa, prazosin Coronary heart disease Beta-blockers, ACE inhibitors, Calcium channel blockers Congestive heart failure ACE inhibitors, beta-blockers 1999 WHO-ISH guidelines

Causes of Resistant Hypertension Improper BP measurement Excess sodium intake Inadequate diuretic therapy Medication Inadequate doses Drug actions and interactions (e.g., (NSAIDs), illicit drugs, sympathomimetics, OCP) Over-the-counter drugs and some herbal supplements Excess alcohol intake Identifiable causes of HTN

take home message -------------- Hypertension is a major cause of morbidity and mortality, and needs to be treated It is an extremely common condition; however it is still underdiagnosed and undertreated Hypertension is easy to diagnose and easy to treat Aim of the management is to save the target organ from the deleterious effect Besides pharmacology we have other choices and one has to be acquainted with that choice Life style modification should always be encouraged in all Hypertensive patients

Any questions?

Que 1) Life style intervention for management of hypertension includes all except: a) b) c) d) Regular aerobic activity 30 min /day Salt intake to 6 gm./day Attain and maintaining BMI 25k/m2 Diets rich in fruits and vegetables and restricted content of saturated fats e) Moderation of alcohol consumption

Que 2) Hypertension management is helpful in the prevention of all except: a) b) c) d) e) Coronary heart disease Heart failure Chronic kidney disease Deep venous thrombosis Cerebrovascular disease

Que 3) Isolated systolic hypertension is common in: a) b) c) d) Young Elderly Pregnancy Blacks

Que 4) Antihypertensive agent recommended for the protection of cardiovascular diseases is: a) b) c) d) e) Calcium channel blockers Diuretics ACE inhibitors Alpha antagonists Central sympatholytic

Que 5) Angiotensin Receptor Blockers play Reno protective effect through all except: a) b) c) d) Decreasing proteinuria Decreasing intraglomerular pressure Preventing endothelial dysfunction Inhibiting conversion of angiotensin-I to angiotensin –II e) Blocking the angiotesin mediated renal remodelling

Que 6) which of the following is the side effect of ACE inhibitors: a) b) c) d) e) Hyperkalaemia Hypercalcemia Hyperglycaemia Hypertension Hypermagnesemia

Que 7) except: a) b) c) d) Calcium channel blockers cause all Pedal oedema Flushing Hyperkalaemia Headache

Que 8) : Safest drug for hypertension in pregnancy is: a) b) c) d) ACE inhibitors Angiotensin receptor blockers Diuretic Methyldopa

Que9) the first line antihypertensive in diabetic patients is: a) b) c) d) Diuretics Angiotensin converting enzyme inhibitors Beta blockers Calcium channel blockers

Que10) which of the following antihypertensive agent is relatively contraindicated in congestive cardiac failure: a) b) c) d) ACE inhibitors Angiotensin receptor blockers Beta blockers Diuretics